Article
Manganese redistribution by calcium-stimulated vesicle trafficking bypasses the need for P-type ATPase function.
The Journal of biological chemistry - 10 Apr 2015
García-Rodríguez Néstor, Manzano-López Javier, Muñoz-Bravo Miguel, Fernández-García Elisabet, Muñiz Manuel, Wellinger Ralf Erik
Abstract excerpt
Regulation of intracellular ion homeostasis is essential for eukaryotic cell physiology. An example is provided by loss of ATP2C1 function, which leads to skin ulceration, improper keratinocyte adhesion, and cancer formation in Hailey-Hailey patients. The yeast ATP2C1 orthologue PMR1 codes for a Mn(2+)/Ca(2+) transporter that is crucial for cis-Golgi manganese supply. Here, we present evidence that calcium...
Topics
- ATP-Binding Cassette Transporters
- Calcium
- Calcium-Transporting ATPases
- Cation Transport Proteins
- Endoplasmic Reticulum
- Endosomes
- Gene Expression Profiling
- Golgi Apparatus
- Green Fluorescent Proteins
- Humans
- Manganese
- Microscopy, Fluorescence