Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in histones dysregulate copper homeostasis leading to defect in Sec61-dependent protein translocation mechanism in Saccharomyces cerevisiae.

The Journal of biological chemistry - 1 Feb 2025

Acharjee Santoshi, Pal Rajshree, Anand Smriti, Thakur Prateeksha, Anjana Vandana, Singh Ranu, Paul Mrittika, Biswas Ashis, Tomar Raghuvir Singh

Abstract excerpt

The translocation of proteins from the cytoplasm to the endoplasmic reticulum occurs via a conserved Sec61 protein channel. Previously, we reported that mutations in histones cause downregulation of a CUP1 copper metallothionein, and copper exposure inhibits the activity of Sec61. However, the role of epigenetic dysregulation on the activity of channel is not clear. Identification of cellular factors regulating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Copper
Share to Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeostasis

Share to Metallothionein

Share to Protein Transport

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to SEC Translocation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 39793894
DOI: 10.1016/j.jbc.2025.108163
PMCID: PMC11847117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in histones dysregulate copper homeostasis leading to defect in Sec61-dependent protein translocation mechanism in Saccharomyces cerevisiae.PMID 39793894Read ↗

Metabolic regulation of copper homeostasis governs the Sec61-dependent protein translocation process in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

The N-Terminal Tail of Histone H3 Regulates Copper Homeostasis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Gene expression profiling and phenotype analyses of S. cerevisiae in response to changing copper reveals six genes with new roles in copper and iron metabolism.Semantic proximity Read ↗

Unresolved questions in human copper pump mechanisms.Semantic proximity Read ↗

Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants.Semantic proximity Read ↗

Histone H2A and Spt10 cooperate to regulate induction and autoregulation of the CUP1 metallothionein.Semantic proximity Read ↗

Transcriptional remodelling in response to changing copper levels in the Wilson and Menkes disease model of Saccharomyces cerevisiae.Semantic proximity Read ↗

Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis.Semantic proximity Read ↗

Molecular mechanisms of copper homeostasis.Semantic proximity Read ↗

Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria.Semantic proximity Read ↗

Critical roles for the COOH terminus of the Cu-ATPase ATP7B in protein stability, trans-Golgi network retention, copper sensing, and retrograde trafficking.Semantic proximity Read ↗

Dfm1 promotes Ste24-dependent translocon quality controlSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.