Article

D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity

2020-06-20

Abstract excerpt

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein that mediates SARS-CoV-2 entry into host cells is a major target for vaccines and therapeutics. Thus, insights into its sequence variations are key to understanding the infection and antigenicity of SARS-CoV-2. A dominant mutational variant at position 614 of the S protein (aspartate...

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Literature Corpus work: 1aff2a96-4462-59c9-b3fe-54a51db7c0c7
DOI: 10.1101/2020.06.20.161323

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