Article

The yeast CST and Polα/primase complexes act in concert to ensure proper telomere maintenance and protection

2024-12-20

Abstract excerpt

Polα/primase, the polymerase that initiates DNA synthesis at replication origins, also completes the task of genome duplication by synthesizing the telomere C-strand under the control of the CST complex. Using cryo-EM structures of the human CST-Polα/primase-DNA complex as guides in conjunction with AlphaFold modeling, we identified structural elements in yeast CST and Polα/primase that promote complex formation....

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Literature Corpus work: d3249b10-cf2e-519a-8242-7e0a5cc90783
DOI: 10.1101/2024.12.20.629258

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