Back to search

Article

Regulation of hematopoietic stem cell (HSC) proliferation by Epithelial Growth Factor Like-7 (EGFL7)

2025-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Understanding the pathways regulating normal and malignant hematopoietic stem cell (HSC) biology is important for improving outcomes for patients with hematologic disorders. Epithelial Growth Factor Like-7 (EGFL7 ) is ∼30 kDa secreted protein that is highly expressed in adult HSCs. Using Egfl7 genetic knock-out ( Egfl7 KO) mice and recombinant EGFL7 (rEGFL7) protein, we examined the role of E...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0a11c03e-4062-5a96-9947-6a720302d757
DOI
10.1101/2025.01.21.634107
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Regulation of hematopoietic stem cell (HSC) proliferation by Epithelial Growth Factor Like-7 (EGFL7)DOI 10.1101/2025.01.21.634107
p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stressSemantic proximity
Hematopoietic Stem Cells: Transcriptional Regulation, Ex Vivo Expansion and Clinical ApplicationSemantic proximity
Smad7 promotes self-renewal of hematopoietic stem cellsSemantic proximity
Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cellsSemantic proximity
Fbxw7 in cell cycle exit and stem cell maintenance: Insight from gene-targeted miceSemantic proximity
Fibroblast growth factor signaling in embryonic and cancer stem cellsSemantic proximity
Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice.Semantic proximity
Endomucin marks quiescent long-term multi-lineage repopulating hematopoietic stem cells and is essential for their transendothelial migrationSemantic proximity
Epidermal growth factor receptor–dependent DNA repair promotes murine and human hematopoietic regenerationSemantic proximity
Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycleSemantic proximity
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.Semantic proximity
IL-7 receptor signaling drives human B-cell progenitor differentiation and expansionSemantic proximity
Select a neighboring publication to make it the new centre.