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Article

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.

Nature immunology - 1 Jul 2008

Loughran Stephen J, Kruse Elizabeth A, Hacking Douglas F, de Graaf Carolyn A, Hyland Craig D, Willson Tracy A, Henley Katya J, Ellis Sarah, Voss Anne K, Metcalf Donald, Hilton Douglas J, Alexander Warren S, Kile Benjamin T

Abstract excerpt

Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of...

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Source

Identifiers

PMID: 18500345
DOI: 10.1038/ni.1617

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.PMID 18500345Read ↗

<i>ERG</i> Is a Megakaryocytic OncogeneSemantic proximity Read ↗

Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.Semantic proximity Read ↗

Germ line ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition.Semantic proximity Read ↗

Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias.Semantic proximity Read ↗

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemiaSemantic proximity Read ↗

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancerSemantic proximity Read ↗

Ets Family Protein, Erg Expression in Developing and Adult Mouse Tissues by a Highly Specific Monoclonal AntibodySemantic proximity Read ↗

Dynamic activity of <i>Erg</i> promotes aging of the hematopoietic systemSemantic proximity Read ↗

Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice.Semantic proximity Read ↗

The Proto-Oncogene ERG in Megakaryoblastic LeukemiasSemantic proximity Read ↗

Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.Semantic proximity Read ↗

Mouse models in the study of the Ets family of transcription factors.Semantic proximity Read ↗

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