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Hematopoietic Stem Cells: Transcriptional Regulation, Ex Vivo Expansion and Clinical Application

5 Dec 2011

Abstract excerpt

Maintenance of ex vivo hematopoietic stem cells (HSC) pool and its differentiated progeny is regulated by complex network of transcriptional factors, cell cycle proteins, extracellular matrix, and their microenvironment through an orchestrated fashion. Strides have been made to understand the mechanisms regulating in vivo quiescence and proliferation of HSCs to develop strategies for ex vivo expansion. Ex vivo...

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PMID: 22082480
DOI: 10.2174/156652412798376125

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