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Epidermal growth factor receptor–dependent DNA repair promotes murine and human hematopoietic regeneration

5 May 2020

Abstract excerpt

Chemotherapy and irradiation cause DNA damage to hematopoietic stem cells (HSCs), leading to HSC depletion and dysfunction and the risk of malignant transformation over time. Extrinsic regulation of HSC DNA repair is not well understood, and therapies to augment HSC DNA repair following myelosuppression remain undeveloped. We report that epidermal growth factor receptor (EGFR) regulates DNA repair in HSCs...

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PMID: 32369572
DOI: 10.1182/blood.2020005895

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