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Article

Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice.

PloS one - 1 Jan 2015

Wang Changshan, Oshima Motohiko, Sashida Goro, Tomioka Takahisa, Hasegawa Nagisa, Mochizuki-Kashio Makiko, Nakajima-Takagi Yaeko, Kusunoki Yoichiro, Kyoizumi Seishi, Imai Kazue, Nakachi Kei, Iwama Atsushi

Abstract excerpt

Precise understanding of radiation effects is critical to develop new modalities for the prevention and treatment of radiation-induced damage. We previously reported that non-lethal doses of X-ray irradiation induce DNA damage in human hematopoietic stem and progenitor cells (HSPCs) reconstituted in NOD/Shi-scid IL2rγnull (NOG) immunodeficient mice and severely compromise their repopulating capacity. In this...

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Source

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Identifiers

PMID: 26161905
DOI: 10.1371/journal.pone.0132041
PMCID: PMC4498777

Genes

NOG
EBF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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