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Article

Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells

22 May 2014

Abstract excerpt

In addition to the properties of self-renewal and multipotency, stem cells are characterised by their distinct cell cycle status. Somatic stem cells are maintained in a quiescent state but switch reversibly from quiescence to proliferation as needed. On the other hand, embryonic stem cells and induced pluripotent stem cells proliferate rapidly until the induction of differentiation results in inhibition of cell...

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PMID: 24853181
DOI: 10.1038/bjc.2014.259

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