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Article

Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle

28 May 2024

Abstract excerpt

ABSTRACT: Loss of long-term hematopoietic stem cell (LT-HSC) function ex vivo hampers the success of clinical protocols that rely on culture. However, the kinetics and mechanisms through which this occurs remain incompletely characterized. In this study, through time-resolved single-cell RNA sequencing, matched in vivo functional analysis, and the use of a reversible in vitro system of early G1 arrest, we defined...

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PMID: 38805639
DOI: 10.1182/blood.2023021426

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