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Article

Smad7 promotes self-renewal of hematopoietic stem cells

18 Aug 2006

Abstract excerpt

The Smad-signaling pathway downstream of the transforming growth factor-beta superfamily of ligands is an evolutionarily conserved signaling circuitry with critical functions in a wide variety of biologic processes. To investigate the role of this pathway in the regulation of hematopoietic stem cells (HSCs), we have blocked Smad signaling by retroviral gene transfer of the inhibitory Smad7 to murine HSCs. We...

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PMID: 16917010
DOI: 10.1182/blood-2006-02-005611

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