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Article

Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway.

Neuron - 18 Dec 2024

Kim Ji-Il, Miura Yuki, Li Min-Yin, Revah Omer, Selvaraj Sridhar, Birey Fikri, Meng Xiangling, Thete Mayuri Vijay, Pavlov Sergey D, Andersen Jimena, Pașca Anca M, Porteus Matthew H, Huguenard John R, Pașca Sergiu P

Abstract excerpt

Abnormalities in thalamocortical crosstalk can lead to neuropsychiatric disorders. Variants in CACNA1G, which encodes the α1G subunit of the thalamus-enriched T-type calcium channel, are associated with absence seizures, intellectual disability, and schizophrenia, but the cellular and circuit consequences of these genetic variants in humans remain unknown. Here, we developed a human assembloid model of the...

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Identifiers

PMID: 39419023
DOI: 10.1016/j.neuron.2024.09.020

Genes

CACNA1G

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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