Article

Human assembloids reveal the consequences of <i>CACNA1G</i> gene variants in the thalamocortical pathway

2023-03-17

Abstract excerpt

Abnormalities in crosstalk between the thalamus and the cerebral cortex are thought to lead to severe neuropsychiatric disorders, such as epilepsy and psychotic disorders. Pathogenic variants in the CACNA1G gene, which encodes the α1G subunit of the thalamus-enriched T-type voltage-gated calcium channel CaV3.1, are associated with absence seizures, intellectual disability, and schizophrenia, but the cellular and c...

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Literature Corpus work: 7d18568e-47ab-5a95-b825-4b9029bfa441
DOI: 10.1101/2023.03.15.530726

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