Article

Cell-specific exon methylation and CTCF binding in neurons regulates calcium ion channel splicing and function

2019-12-15

Abstract excerpt

<h4>Summary</h4> Cell-specific alternative splicing modulates myriad cell functions and this process is disrupted in disease. The mechanisms governing alternative splicing are known for relatively few genes and typically focus on RNA splicing factors. In sensory neurons, cell-specific alternative splicing of the presynaptic voltage-gated calcium channel Cacna1b gene modulates opioid sensitivity. How this splicin...

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Literature Corpus work: d7639143-9313-57c2-9c9f-77eb6043d2e7
DOI: 10.1101/2019.12.15.876185

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