Article

Linked origins but distinct roles for extreme length and sequence variation at a tandem repeat in <i>CACNA1C</i>

2026-04-23

Abstract excerpt

Length variation in tandem repeats is a well-established driver of disease risk and is commonly assumed to arise from persistent genomic instability. Here, we characterize TRACT, a 30-bp variable number tandem repeat (VNTR) intronic to the calcium channel gene CACNA1C . TRACT exhibits extreme length variation (3-30+ kb) and has been previously linked to risk for bipolar disorder and schizophrenia. By examining mu...

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Literature Corpus work: 017a2a8d-1f8c-520a-a5ba-f8e025d08532
DOI: 10.64898/2026.04.23.720446

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