Article

Characterization of a human-specific tandem repeat associated with bipolar disorder and schizophrenia

2018-05-01

Abstract excerpt

Bipolar disorder (BD) and schizophrenia (SCZ) are highly heritable diseases that affect over 3% of individuals worldwide. Genomewide association studies have strongly and repeatedly linked risk for both of these neuropsychiatric diseases to a 100 kb interval in the third intron of the human calcium channel gene CACNA1C. However, the causative mutation is not yet known. We have identified a novel human-specific ta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6fda0941-c66a-5e12-a3e9-9b1fc2a6fff8
DOI: 10.1101/311795

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterization of a human-specific tandem repeat associated with bipolar disorder and schizophreniaDOI 10.1101/311795Read

Characterization of a Human-Specific Tandem Repeat Associated with Bipolar Disorder and Schizophrenia.Semantic proximity Read

Linked origins but distinct roles for extreme length and sequence variation at a tandem repeat in <i>CACNA1C</i>Semantic proximity Read

Structural characterization of a polymorphic repeat at the CACNA1C schizophrenia locusSemantic proximity Read

Revisiting tandem repeats in psychiatric disorders from perspectives of genetics, physiology, and brain evolution.Semantic proximity Read

Human-specific tandem repeat in <i>CACNA1C</i> modulates responses to neuronal stimulationSemantic proximity Read

Genome-wide survey of tandem repeats by nanopore sequencing shows that disease-associated repeats are more polymorphic in the general populationSemantic proximity Read

Rediscovering tandem repeat variation in schizophrenia: challenges and opportunities.Semantic proximity Read

Genome-wide survey of tandem repeats by nanopore sequencing shows that disease-associated repeats are more polymorphic in the general population.Semantic proximity Read

An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia.Semantic proximity Read

Polymorphic CGG repeats in gene regulation and disease.Semantic proximity Read

Functional Characterization of Schizophrenia-Associated Variation in CACNA1C.Semantic proximity Read

Genome-wide Survey of Tandem Repeats by Nanopore Sequencing Shows that Disease-associated Repeats are More Polymorphic in the General PopulationSemantic proximity Read