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Investigating the Stability, Flexibility, and Phase Separation Properties of H46R and H80R Disease Mutants of SOD1: Insights into ALS Pathogenesis.

Biochemistry - 5 Aug 2025

Banerjee Ahana, Sanyal Dwipanjan, Chattopadhyay Krishnananda

Abstract excerpt

Human Cu, Zn superoxide dismutase (SOD1) is the primary enzyme in the cellular antioxidant defense system. Mutations in SOD1 are associated with amyotrophic lateral sclerosis (ALS), where protein misfolding and aggregation contribute to the disease pathology. Recently, SOD1 mutants have been shown to undergo phase separation, forming protein-rich droplets that can serve as precursors to the fibrillar aggregates,...

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PMID: 40673755
DOI: 10.1021/acs.biochem.5c00289

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SOD1

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