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Article

RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation

26 Oct 2019

Abstract excerpt

Cell cycle gene expression occurs in two waves. The G1/S genes encode factors required for DNA synthesis and the G2/M genes contribute to mitosis. The Retinoblastoma protein (RB) and DREAM complex (DP, RB-like, E2F4 and MuvB) cooperate to repress all cell cycle genes during G1 and inhibit entry into the cell cycle. DNA damage activates p53 leading to increased levels of p21 and inhibition of cell cycle...

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PMID: 31667499
DOI: 10.1093/nar/gkz961

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