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Article

Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control.

Molecular cell - 11 Apr 2008

Bhaskara Srividya, Chyla Brenda J, Amann Joseph M, Knutson Sarah K, Cortez David, Sun Zu-Wen, Hiebert Scott W

Abstract excerpt

Histone deacetylases (HDACs) are enzymes that modify key residues in histones to regulate chromatin architecture, and they play a vital role in cell survival, cell-cycle progression, and tumorigenesis. To understand the function of Hdac3, a critical component of the N-CoR/SMRT repression complex, a conditional allele of Hdac3 was engineered. Cre-recombinase-mediated inactivation of Hdac3 led to a delay in...

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Identifiers

PMID: 18406327
DOI: 10.1016/j.molcel.2008.02.030
PMCID: PMC2373760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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