Article
Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions.
Diabetes & vascular disease research - 1 Jan 2000
Thiem Kathrin, Hoeke Geerte, Zhou Enchen, Hijmans Anneke, Houben Tom, Boels Margien G, Mol Isabel M, Lutgens Esther, Shiri-Sverdlov Ronit, Bussink Johan, Kanneganti Thirumala D, Boon Mariëtte R, Stienstra Rinke, Tack Cees J, Rensen Patrick Cn, Netea Mihai G, Berbée Jimmy Fp, van Diepen Janna A
Abstract excerpt
BACKGROUND: C-type lectin receptors, including Dectin-2, are pattern recognition receptors on monocytes and macrophages that mainly recognize sugars and sugar-like structures present on fungi. Activation of C-type lectin receptors induces downstream CARD9 signalling, leading to the production of cytokines. We hypothesized that under hyperglycaemic conditions, as is the case in diabetes mellitus, glycosylated...
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