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Article

CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation.

Clinical science (London, England : 1979) - 1 Oct 2013

Paramel Geena Varghese, Folkersen Lasse, Strawbridge Rona J, Elmabsout Ali Ateia, Särndahl Eva, Lundman Pia, Jansson Jan-Håkan, Hansson Göran K, Sirsjö Allan, Fransén Karin

Abstract excerpt

Inflammation is a key factor in the development of atherosclerotic coronary artery disease. It is promoted through the inflammasome, a molecular machine that produces IL (interleukin)-1β in response to cholesterol crystal accumulation in macrophages. The CARD8 (caspase recruitment domain 8) prote...

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Source

Identifiers

PMID: 23611467
DOI: 10.1042/CS20120572

Genes

CARD8
CRP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23611467-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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