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Article

Targeted disruption in mice of a neural stem cell-maintaining, KRAB-Zn finger-encoding gene that has rapidly evolved in the human lineage.

PloS one - 1 Jan 2012

Chien Huan-Chieh, Wang Hurng-Yi, Su Yi-Ning, Lai Kuan-Yu, Lu Li-Chen, Chen Pau-Chung, Tsai Shih-Feng, Wu Chung-I, Hsieh Wu-Shiun, Shen Che-Kun James

Abstract excerpt

Understanding the genetic basis of the physical and behavioral traits that separate humans from other primates is a challenging but intriguing topic. The adaptive functions of the expansion and/or reduction in human brain size have long been explored. From a brain transcriptome project we have identified a KRAB-Zn finger protein-encoding gene (M003-A06) that has rapidly evolved since the human-chimpanzee...

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Identifiers

PMID: 23071813
DOI: 10.1371/journal.pone.0047481
PMCID: PMC3468564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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