Article

Highly efficient and low-cost single-cell culture platform for unbiased analysis of human memory B cell repertoire and antibody discovery

2025-01-16

Abstract excerpt

The SARS-CoV-2 pandemic underscored the need for innovative approaches to study humoral immunity and isolate monoclonal antibodies (mAbs) with diagnostic and therapeutic potential. Current methods for repertoire analysis at the clonal level require large-scale recombinant mAb production, limiting accessibility and delaying functional insight. We developed a single-cell culture (SCC) platform that enables profiling...

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Literature Corpus work: 60957417-d953-53ea-bef8-b6bfc6f69c97
DOI: 10.1101/2025.01.14.25320505

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