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Article

Visualization of oligonucleotide probes and point mutations in interphase nuclei and DNA fibers using rolling circle DNA amplification.

Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2001

Zhong X B, Lizardi P M, Huang X H, Bray-Ward P L, Ward D C

Abstract excerpt

Rolling circle amplification (RCA) is a surface-anchored DNA replication reaction that can be exploited to visualize single molecular recognition events. Here we report the use of RCA to visualize target DNA sequences as small as 50 nts in peripheral blood lymphocytes or in stretched DNA fibers....

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Identifiers

PMID: 11274414
DOI: 10.1073/pnas.061026198
PMCID: PMC31158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11274414-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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