Article

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor

2023-09-12

Abstract excerpt

Cellular senescence is now acknowledged as a key contributor to organismal ageing and late-life disease. Although popular, the study of senescence in vitro can be complicated by the prolonged and asynchronous timing of cells committing to it and its paracrine effects. To address these issues, we repurposed the small molecule inhibitor inflachromene (ICM) to induce senescence to human primary cells. Within six day...

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Literature Corpus work: 09712f11-28f6-58a9-a257-3de2c0bb072d
DOI: 10.1101/2023.09.07.556710

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