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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span.

Annual review of pharmacology and toxicology - 6 Jan 2021

Robbins Paul D, Jurk Diana, Khosla Sundeep, Kirkland James L, LeBrasseur Nathan K, Miller Jordan D, Passos João F, Pignolo Robert J, Tchkonia Tamar, Niedernhofer Laura J

Abstract excerpt

Senescence is the consequence of a signaling mechanism activated in stressed cells to prevent proliferation of cells with damage. Senescent cells (Sncs) often develop a senescence-associated secretory phenotype to prompt immune clearance, which drives chronic sterile inflammation and plays a causal role in aging and age-related diseases. Sncs accumulate with age and at anatomical sites of disease. Thus, they are...

Topics

Aged
Aging
Cellular Senescence
Humans
Pharmaceutical Preparations
Phenotype
Signal Transduction

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32997601
DOI: 10.1146/annurev-pharmtox-050120-105018
PMCID: PMC7790861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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