Article
Immunotherapeutic approach to reduce senescent cells and alleviate senescence-associated secretory phenotype in mice.
Aging cell - 1 May 2023
Shrestha Niraj, Chaturvedi Pallavi, Zhu Xiaoyun, Dee Michael J, George Varghese, Janney Christopher, Egan Jack O, Liu Bai, Foster Mark, Marsala Lynne, Wong Pamela, Cubitt Celia C, Foltz Jennifer A, Tran Jennifer, Schappe Timothy, Hsiao Karin, Leclerc Gilles M, You Lijing, Echeverri Christian, Spanoudis Catherine, Carvalho Ana, Kanakaraj Leah, Gilkes Crystal, Encalada Nicole, Kong Lin, Wang Meng, Fang Byron, Wang Zheng, Jiao Jin-An, Muniz Gabriela J, Jeng Emily K, Valdivieso Nicole, Li Liying, Deth Richard, Berrien-Elliott Melissa M, Fehniger Todd A, Rhode Peter R, Wong Hing C
Abstract excerpt
Accumulation of senescent cells (SNCs) with a senescence-associated secretory phenotype (SASP) has been implicated as a major source of chronic sterile inflammation leading to many age-related pathologies. Herein, we provide evidence that a bifunctional immunotherapeutic, HCW9218, with capabilities of neutralizing TGF-β and stimulating immune cells, can be safely administered systemically to reduce SNCs and...
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