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Disrupting the Senescence-Associated Secretory Phenotype-M1Macrophage Feedback Loop in Synovitis Using Dual Nano-Switches To Restore Joint Homeostasis.

ACS nano - 17 Feb 2026

Zhang Jing, Li Xinghua, Wang Ping, Liu Xin, Guo Wuqi, Si Jia, Huo Qiang, Xu Ming, Liu Yang, Niu Yimin

Abstract excerpt

Osteoarthritis (OA), a leading cause of disability worldwide, impacts over 300 million people through progressive joint degeneration marked by chronic pain and functional impairment. A key driver of osteoarthritis progression is synovitis, characterized by inflamed synovial tissue harboring senescent fibroblasts and pro-inflammatory macrophages. These senescent cells secrete senescence-associated secretory...

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PMID: 41636104
DOI: 10.1021/acsnano.5c15543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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