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Plasma and CSF neurofilament light chain are stabilized in response to mutant huntingtin lowering in the brain of Huntington disease mice

2024-05-22

Abstract excerpt

<title>Abstract</title> <p>Background Therapeutic approaches aimed at lowering levels of toxic mutant huntingtin (mHTT) in the brain can reverse disease phenotypes in animal models of Huntington disease (HD) and are currently being evaluated in clinical trials. Sensitive and dynamic response biomarkers are needed to assess the efficacy of such candidate therapies. Neurofilament light chain (NfL) is a biomarker o...

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Literature Corpus work
093c5851-7e4b-54de-a5cb-a8cbdc7ab218
DOI
10.21203/rs.3.rs-4378780/v1
Open publication

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Plasma and CSF neurofilament light chain are stabilized in response to mutant huntingtin lowering in the brain of Huntington disease miceDOI 10.21203/rs.3.rs-4378780/v1
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