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Article

Huntingtin-lowering strategies for Huntington's disease.

Expert opinion on investigational drugs - 1 Oct 2020

Barker Roger A, Fujimaki Motoki, Rogers Priya, Rubinsztein David C

Abstract excerpt

INTRODUCTION: Huntington's disease (HD) is an incurable, autosomal dominant neurodegenerative disease caused by an abnormally long polyglutamine tract in the huntingtin protein. Because this mutation causes disease via gain-of-function, lowering huntingtin levels represents a rational therapeutic strategy. AREAS COVERED: We searched MEDLINE, CENTRAL, and other trial databases, and relevant company and HD funding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32745442
DOI: 10.1080/13543784.2020.1804552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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