Article

Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model

2022-05-18

Abstract excerpt

We have developed a novel inducible Huntington’s disease (HD) mouse model that allows temporal control of whole-body allele-specific mutant Huntingtin (m Htt ) expression. We asked whether moderate global lowering of m Htt (∼50%) was sufficient for long-term amelioration of HD-related deficits and, if so, whether early m Htt lowering (before measurable deficits) was required. Both early and late m Htt lowerin...

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Literature Corpus work: b4350eb4-b9d3-5687-ada1-795b46e214c5
DOI: 10.1101/2022.05.17.492356

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