Article

Lis1 mutation prevents basal radial glia-like cell production in the mouse

2020-10-10

Abstract excerpt

Human cortical malformations are associated with progenitor proliferation and neuronal migration abnormalities. Progenitor cells include apical radial glia, intermediate progenitors and basal (or outer) radial glia (bRGs or oRGs). bRGs are few in number in lissencephalic species (e.g. the mouse) but abundant in gyrencephalic brains. The LIS1 gene coding for a dynein regulator, is mutated in human lissencephaly, a...

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Literature Corpus work: 0936daae-2002-5498-a576-b5fb4920c737
DOI: 10.1101/2020.10.10.334508

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