Article
Impaired proliferation and migration in human Miller-Dieker neural precursors.
Annals of neurology - 1 Jul 2006
Sheen Volney L, Ferland Russell J, Harney Megan, Hill R Sean, Neal Jason, Banham Alison H, Brown Philip, Chenn Anjen, Corbo Joseph, Hecht Jonathan, Folkerth Rebecca, Walsh Christopher A
Abstract excerpt
OBJECTIVE: Miller-Dieker syndrome (MDS) is a malformation of cortical development that results in lissencephaly (meaning smooth brain). This disorder is caused by heterozygous deletions on chromosome 17p13.3, including the lissencephaly 1 (LIS1) gene. Various mouse models have been used as an experimental paradigm in understanding human lissencephaly, but clear limitations exist in these studies, particularly...
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