Article

LIS1 is critical for axon integrity in adult mice

2025-10-21

Abstract excerpt

Mutations in human LIS1 cause lissencephaly, a severe developmental brain malformation. Although most studies focus on development, LIS1 is also expressed in adult mouse tissues. We previously induced LIS1 knockout (iKO) in adult mice using a Cre-Lox approach with an actin promoter driving CreERT2 expression. This proved to be rapidly lethal, with evidence pointing toward nervous system dysfunction. CreERT2 activi...

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Literature Corpus work: 45bfca8b-bf7d-5e61-9f0e-737b61e40b95
DOI: 10.1101/2025.10.20.683562

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