Article
Lissencephaly and the molecular basis of neuronal migration.
Human molecular genetics - 1 Apr 2003
Kato Mitsuhiro, Dobyns William B
Abstract excerpt
Migration of post-mitotic neurons from the ventricular zone to the cortical plate during embryogenesis comprises one of the most critical stages in brain development. Deficiency of this process often results in major brain malformations, including human lissencephaly (smooth brain). Since discovery of the first genetic cause of lissencephaly, deletions of chromosome 17p13.3 in Miller-Dieker syndrome, rapid...
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