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Article

Genetic mechanisms underlying abnormal neuronal migration in classical lissencephaly.

Trends in genetics : TIG - 1 Dec 2007

Kerjan Geraldine, Gleeson Joseph G

Abstract excerpt

Classical lissencephaly is a human developmental brain disorder characterized by a paucity of cortical gyration and thickening of the cortical gray matter, leading to severe epilepsy and mental retardation. Loss-of-function mutations in the microtubule-associated protein encoding genes, PAFAH1B1 (encoding the protein LIS1), DCX and TUBA1A have been implicated in the pathogenesis of the condition. Animal models...

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Source

Identifiers

PMID: 17997185
DOI: 10.1016/j.tig.2007.09.003

Genes

DCX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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