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Article

LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages.

The Journal of cell biology - 12 Sept 2005

Tsai Jin-Wu, Chen Yu, Kriegstein Arnold R, Vallee Richard B

Abstract excerpt

Mutations in the human LIS1 gene cause the smooth brain disease classical lissencephaly. To understand the underlying mechanisms, we conducted in situ live cell imaging analysis of LIS1 function throughout the entire radial migration pathway. In utero electroporation of LIS1 small interference RNA and short hairpin dominant negative LIS1 and dynactin cDNAs caused a dramatic accumulation of multipolar progenitor...

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Identifiers

PMID: 16144905
DOI: 10.1083/jcb.200505166
PMCID: PMC2171430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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