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Article

Lis1 mutation prevents basal radial glia-like cell production in the mouse.

Human molecular genetics - 21 Mar 2022

Penisson Maxime, Jin Mingyue, Wang Shengming, Hirotsune Shinji, Francis Fiona, Belvindrah Richard

Abstract excerpt

Human cerebral cortical malformations are associated with progenitor proliferation and neuronal migration abnormalities. Progenitor cells include apical radial glia, intermediate progenitors and basal (or outer) radial glia (bRGs or oRGs). bRGs are few in number in lissencephalic species (e.g. the mouse) but abundant in gyrencephalic brains. The LIS1 gene coding for a dynein regulator, is mutated in human...

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PMID: 34635911
DOI: 10.1093/hmg/ddab295

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