Article

A new humanized TCR transgenic mouse model to study citrullinated tenascin C reactive T cells relevant to rheumatoid arthritis

2026-02-14

Abstract excerpt

<h4>Objectives</h4> Autoreactive T cells recognizing citrullinated antigens, although rare and difficult to study, are implicated in rheumatoid arthritis (RA). To allow functional studies and manipulation of such T cells, we have generated and characterized transgenic mice expressing a TCR cloned from an RA patient and reactive with a prominent target, citrullinated tenascin C (citTNC). <h4>Methods</h4> A humani...

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Literature Corpus work: 09294883-e150-5f44-ac83-69d2a3029ca2
DOI: 10.64898/2026.02.12.705563

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