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Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis

24 Feb 2023

Abstract excerpt

Cryptic peptides, hidden from the immune system under physiologic conditions, are revealed by changes to MHC class II processing and hypothesized to drive the loss of immune tolerance to self-antigens in autoimmunity. Rheumatoid arthritis (RA) is an autoimmune disease characterized by immune responses to citrullinated self-antigens, in which arginine residues are converted to citrullines. Here, we investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36828807
DOI: 10.1038/s41467-023-36620-y

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