Article

Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritis

2021-11-15

Abstract excerpt

<h4>Objectives: </h4> To search for common features in the autoreactive T cell receptor (TCR)-repertoire in patients with rheumatoid arthritis (RA), focusing on the newly identified candidate antigen citrullinated Tenascin C (cit-TNC). Methods Mononuclear cells from peripheral blood or synovial fluid of eight RA-patients positive for the RA-associated HLA-DRB1*04:01 allele were in-vitro cultured with recently ide...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a841147-5bfc-5ac3-9db1-e6dc5a80ec6a
DOI: 10.21203/rs.3.rs-956289/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritisDOI 10.21203/rs.3.rs-956289/v1Read

A new humanized TCR transgenic mouse model to study citrullinated tenascin C reactive T cells relevant to rheumatoid arthritisSemantic proximity Read

The molecular basis underlying T cell specificity towards citrullinated epitopes presented by HLA-DR4Semantic proximity Read

Pathogenic Citrulline‐Multispecific B Cell Receptor Clades in Rheumatoid ArthritisSemantic proximity Read

T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles.Semantic proximity Read

Autoantigen-specific CD8+ T-cell signature in Rheumatoid ArthritisSemantic proximity Read

Effects of type II collagen epitope carbamylation and citrullination in human leucocyte antigen (HLA)-DR4(+) monozygotic twins discordant for rheumatoid arthritis.Semantic proximity Read

Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritisSemantic proximity Read

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.Semantic proximity Read

Beyond autoantibodies: Biological roles of human autoreactive B cells in rheumatoid arthritis revealed by whole transcriptome profilingSemantic proximity Read

Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA‐SequencingSemantic proximity Read

Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+ T Lymphocyte Signature.Semantic proximity Read

Citrullination only infrequently impacts peptide binding to HLA class II MHC.Semantic proximity Read