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Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice

7 Apr 2008

Abstract excerpt

Rheumatoid arthritis (RA) is a common autoimmune disease that afflicts the synovium of diarthrodial joints. The pathogenic mechanisms inciting this disease are not fully characterized, but may involve the loss of tolerance to posttranslationally modified (citrullinated) antigens. We have demonstrated that this modification leads to a selective increase in antigenic peptide affinity for major histocompatibility...

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PMID: 18391064
DOI: 10.1084/jem.20072051

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