Article

SMARCB1 loss creates patient-specific <i>MYC</i> topologies that drive malignant rhabdoid tumor growth

2022-11-22

Abstract excerpt

Malignant rhabdoid tumor (MRT) is a highly malignant and often lethal childhood cancer. MRTs are genetically defined by bi-allelic inactivating mutations in SMARCB1 , a member of the BRG1/BRM-associated factors (BAF) chromatin remodeling complex. Mutations in BAF complex members are common in human cancer, yet their contribution to tumorigenesis remains in many cases poorly understood. Here, we studied derailed r...

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Literature Corpus work: 0907f649-15c6-534b-bd0d-4a992ec6a51a
DOI: 10.1101/2022.11.21.516939

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