Article
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers.
The Journal of clinical investigation - 1 Aug 2012
Lee Ryan S, Stewart Chip, Carter Scott L, Ambrogio Lauren, Cibulskis Kristian, Sougnez Carrie, Lawrence Michael S, Auclair Daniel, Mora Jaume, Golub Todd R, Biegel Jaclyn A, Getz Gad, Roberts Charles W M
Abstract excerpt
Cancer is principally considered a genetic disease, and numerous mutations are thought essential to drive its growth. However, the existence of genomically stable cancers and the emergence of mutations in genes that encode chromatin remodelers raise the possibility that perturbation of chromatin structure and epigenetic regulation are capable of driving cancer formation. Here we sequenced the exomes of 35...
Topics
- Child, Preschool
- Chromatin Assembly and Disassembly
- Chromosomal Proteins, Non-Histone
- DNA Mutational Analysis
- DNA, Neoplasm
- DNA-Binding Proteins
- Exome
- Female
- Humans
- Infant
- Male
- Mutation
- Neoplasm Recurrence, Local