Article

Spatial dissection of ADC/RPT targets defines therapeutic opportunities in rhabdoid tumors

2025-12-13

Abstract excerpt

Rhabdoid tumors (RT) are among the most aggressive pediatric malignancies, characterized by early onset, loss of SWI/SNF complex members (SMARCB1 or SMARCA4), and dismal outcomes despite multimodal therapy. Refractory and relapsing RT remain almost uniformly fatal, and targeted or immune-based approaches have yet to demonstrate clinical benefit. To explore novel therapeutic vulnerabilities, we systematically inves...

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Literature Corpus work: 6e66fefd-2202-54d7-9a43-5d6d1b301d93
DOI: 10.64898/2025.12.11.692900

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