Article

Diverse Mechanisms of <i>SMARCB1</i> Inactivation and Genome Maintenance Defects in Ultra-Rare Malignant Rhabdoid Tumors

2026-03-02

Abstract excerpt

<h4>ABSTRACT</h4> Malignant rhabdoid tumors (MRTs) are extremely rare and highly aggressive pediatric cancers classically defined by biallelic loss of the SMARCB1 gene, with rare involvement of SMARCA4 . However, the molecular mechanisms leading to this loss are not yet fully understood. MRTs occur predominantly in infants, with the highest incidence in children under one year of age. Clinically, they are chara...

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Literature Corpus work: b44c527c-7225-596b-9539-675ef5ce2a77
DOI: 10.64898/2026.02.27.706889

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