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Article

The structural basis for HIV-1 Vif antagonism of human APOBEC3G

8 Feb 2023

Abstract excerpt

. The lentiviruses encode a protein, Vif, that antagonizes A3 family members by targeting them for degradation. Diversification of A3 allows host escape from Vif whereas adaptations in Vif enable cross-species transmission of primate lentiviruses. How this 'molecular arms race' plays out at the structural level is unknown. Here, we report the cryogenic electron microscopy structure of human APOBEC3G (A3G) bound...

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PMID: 36754086
DOI: 10.1038/s41586-023-05779-1

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