Article

Paraoxonase-like APMAP maintains endoplasmic reticulum-associated lipid and lipoprotein homeostasis

2024-01-28

Abstract excerpt

<h4>Summary</h4> Oxidative stress perturbs lipid homeostasis and contributes to metabolic diseases. Though ignored compared to mitochondrial oxidation, the endoplasmic reticulum (ER) generates reactive oxygen species requiring antioxidant quality control. Using multi-organismal profiling featuring Drosophila , zebrafish, and mammalian cells, here we characterize the paraoxonase-like APMAP as an ER-localized prot...

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Literature Corpus work: 08f313a1-9b78-56f9-9217-652c4dae419a
DOI: 10.1101/2024.01.26.577049

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