Article
trappc11 is required for protein glycosylation in zebrafish and humans.
Molecular biology of the cell - 15 Apr 2016
DeRossi Charles, Vacaru Ana, Rafiq Ruhina, Cinaroglu Ayca, Imrie Dru, Nayar Shikha, Baryshnikova Anastasia, Milev Miroslav P, Stanga Daniela, Kadakia Dhara, Gao Ningguo, Chu Jaime, Freeze Hudson H, Lehrman Mark A, Sacher Michael, Sadler Kirsten C
Abstract excerpt
Activation of the unfolded protein response (UPR) can be either adaptive or pathological. We term the pathological UPR that causes fatty liver disease a "stressed UPR." Here we investigate the mechanism of stressed UPR activation in zebrafish bearing a mutation in thetrappc11gene, which encodes a component of the transport protein particle (TRAPP) complex.trappc11mutants are characterized by secretory pathway...
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